We studied anti-HBs titer, positive and effective rate in relation to dosages(5㎍, 10㎍) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5㎍ of
Hepavax
was administered intramusculary at 1 month, 2 months and 6 months of age, in other group (n=11), 10㎍ of Hepavax at same time interval. And the anti-HBs was studied at 2 months and 3 year after third vaccination by radioimmunoassay.
@ES The results were as follows:
@EN 1) The anti-HBs positive rate was 100% in two groups at 2 months and 3 years after vaccination.
2) The geometric mean anti-HBs titer at 2 months after third vacciantion was 9418.3±13041.5 IU/L in 5㎍ group and 12750.0±12750.5 IU/L in 10㎍ group, and 3 year after vaccination, 949.4±1404.0 IU/L in 5㎍ group, 1067.4±1067.7 IU/L in 10㎍
group.
There were no significant difference between two groups, although mean anti-HBs titer decreased significantly after 3 years.
3) The effective rate at 3 years after vaccination was 66.7% in 5 ㎍group and 72.8% in 10㎍ group. There was no statistical significant difference between two groups.
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